The Organic Chemistry of Drug Design and Drug Action por Richard B. Silverman Ph.D Organic Chemistry,Mark W. Holladay

March 30, 2020

Obtenga el libro de The Organic Chemistry of Drug Design and Drug Action de Richard B. Silverman Ph.D Organic Chemistry,Mark W. Holladay en formato PDF o EPUB. Puedes leer cualquier libro en línea o guardarlo en tus dispositivos. Cualquier libro está disponible para descargar sin necesidad de gastar dinero.

The Organic Chemistry of Drug Design and Drug Action por Richard B. Silverman Ph.D Organic Chemistry,Mark W. Holladay
Titulo del libro : The Organic Chemistry of Drug Design and Drug Action
Autor : Richard B. Silverman Ph.D Organic Chemistry,Mark W. Holladay

Richard B. Silverman Ph.D Organic Chemistry,Mark W. Holladay con The Organic Chemistry of Drug Design and Drug Action

Críticas ""This book is a tour de force in the title area....This book adopts a novel format that focuses on the rational chemical underpinnings to both drug discovery and drug development. It seeks to illuminate the workings of drugs at the molecular level. Thus, this book contrasts with the traditional presentation which is organized around various classes of drugs....This book would be appropriate for advanced undergraduate students and graduate students and would probably be well suited as a text for course applications, especially at the graduate level. It is strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."" --Bruce E. Maryanoff, R.W. Jouhnson Pharnaceutical Research Institute, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vo. 115, No.12, 1993 ""For the first time the principles of medicinal chemistry/pharmacology are collected in a unified, well-organized and clearly presented fashion. It is so clearly written that it will be of value to both students and veteran scientists...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data so as to truly begin to reduce medicinal chemistry from a hybrid of chemistry, pharmacology and related sciences to a single, clearly defined, rationalized discipline."" --CARL KAISER, Ph.D., Director, Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION ""The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way...The book will turn out to be very popular with students because the material is presented clearly...The numerous superbillustrations included are used very effectively by the author to communicate and/or clarify concepts and ideas."" --William C. Groutas, Ph.D., Professor of Chemistry, WICHITA STATE UNIVERSITY ""I find [Chapter 8] to be an unusually comprehensive, clear and well organized discussion on prodrugs. Although the concepts are complex, they are presented in a logical, easily understood format. Dr. Silverman's use of schematics to illustrate both chemical and biochemical principles is especially effective and should be easily comprehended by the intended audience. I found myself reading for interest and enjoyment rather than searching for mistakes. The references are focused and current. It should become a standard text in short order."" --Anthony A. Sinkula, Ph.D., THE UPJOHN COMPANY ""I was favorably impressed with the clarity of Dr. Silverman's writing style which made the material interesting and easy to read...Treatment of the material is quite comprehensive without being overly detailed and the referencing and illustrations are well chosen and at about the right level."" --John G. Topliss, Ph.D., PARKE-DAVIS ""This book emphasizes the organic chemical aspects of medicinal chemistry....The organization of this book and the clarity of presentation are outstanding....The book very clearly presents medicinal chemistry as a unified discipline based on sound principles of organic chemistry. It is highly recommended to medicinal chemists as well as to all others entering into the field or concerned with the science of medicinal chemistry."" --JOURNAL OF MEDICINAL CHEMISTRY Reseña del editor The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and referencesChapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the bookChapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistryChapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexantChapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesisChapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinibfor transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazidfor slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptinChapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examplesChapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolitesChapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates Ver Descripción del producto

Los más vendidos Libros Fotomontaje creativo (Photoclub) El Coran The Animator's Survival Kit Klaus: The Art of the Movie Minecraft. Guía visual. Supervivencia, Construcciones y Redstone (Libros Singulares) AMAZON LOCKER FOR BEGINNERS: A Step by Step Beginners Guide on How Amazon Locker Works (Amazon Hub, Whole Food Market) With Pictures. (English Edition) David Busch's Sony Alpha a7R II/a7 II Guide to Digital Photography (David Buschs Guides) Nikon D7200 (Photoclub) EL GRAN LIBRO DE ANDROID 7ª ED.: 1 Autocad 2019. Curso Práctico (Más de 140 ejemplos y ejercicios prácticos) Usabilidad. Deja de sufrir (Social Media) AutoCAD 2020 (Manuales Imprescindibles) Domina Tu Cámara. Descubre Los Secretos De La Fotografía Digital (Foto-Ruta) Helvetica: Homage to a Typeface The Essential Turing: Seminal Writings in Computing, Logic, Philosophy, Artificial Intelligence, and Artificial Life plus The Secrets of Enigma Microsoft Visio 2013 Step By Step: Micro Visio 2013 Step St_p1 (English Edition) Fundamentals of Data Visualization: A Primer on Making Informative and Compelling Figures Guía práctica de Revit: Volumen 1 ACTIC 2: qüestionaris de preguntes d'examen ZBrush Characters and Creatures No me hagas pensar. Actualización (Títulos Especiales) Qüestionaris de preguntes d'examen: ACTIC 1 Foundations of Game Engine Development, Volume 2: Rendering Game Engine Gems 3 (English Edition) Game Engine Gems 2 (English Edition) El retrato dramático: El arte de crear luces y sombras (Photoclub) Marketing en Redes Sociales : Marketing en Facebook, Marketing en Youtube, Marketing en Instagram (Libro en Español/Social Media Marketing Book Spanish Version) Real-Time Rendering, Fourth Edition Photoshop CS6. Superfácil Técnicas de animación. Dibujos animados, animación 3D y videojuegos (Espacio De Diseño) Org Design for Design Orgs: Building and Managing In-House Teams GuíaBurros Youtube: Todo lo que necesitas saber sobre esta red social: 58 Alexa Echo Instructions: 550 Funny Things to Ask Alexa (2017 Edition): (Works with Amazon Echo, Amazon Dot, Amazon Tap) (English Edition) The Deep-sky Imaging Primer, Second Edition La fotografía móvil (Photoclub) Dragon Age: The World Of Thedas Volume 2 Fotografía foodie. Cómo crear imágenes apetitosas (Photoclub) LEVEL UP! Guía para ser un gran diseñador de videojuegos (Diseño Multimedia) Cómo Crecer Rápido en Youtube: (Y Ganar Dinero) The Art of Diablo Sketching from Imagination in ZBrush (Sketching from the Imagination) Fotografía para todos: más de 300 trucos y consejos de los grandes expertos Lo mejor de la fotografía digital (Photoclub) Arquímedes 2016 (Manuales Imprescindibles) Building with Virtual LEGO: Getting Started with LEGO Digital Designer, LDraw, and Mecabricks La luz. Ciencia y magia (Photoclub) La Fotografía Digital con Scott Kelby. Vol II (Photoclub) Level Up! The Guide to Great Video Game Design PowerPoint 2010 y presentaciones para Dummies: Guía rápida Revit Architecture 2019 (Manuales Imprescindibles)